Structure-Function Mapping of the Nuclear Pore Complex
نویسندگان
چکیده
منابع مشابه
Structure and function of the nuclear pore complex.
Javier Fernandez-Martinez1,7, Seung Joong Kim2,7, Yi Shi3,7, Paula Upla4,7, Riccardo Pellarin2,6,7, Michael Gagnon5, Ilan E. Chemmama2, Junjie Wang3, Ilona Nudelman1, Wenzhu Zhang3, Rosemary Williams1, William J. Rice4, David L. Stokes4, Daniel Zenklusen5, Brian T. Chait3,*, Andrej Sali2,*, and Michael P. Rout1,* 1Laboratory of Cellular and Structural Biology, The Rockefeller University, New Yo...
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In eukaryotic cells, the spatial segregation of replication and transcription in the nucleus and translation in the cytoplasm imposes the requirement of transporting thousands of macromolecules between these two compartments. Nuclear pore complexes (NPCs) are the sole gateways that facilitate this macromolecular exchange across the nuclear envelope with the help of soluble transport receptors. ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2019
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2018.11.833